期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 49, 期 8, 页码 2363-2366出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm060112m
关键词
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Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor, At present, ellagic acid represents the most potent known CK2 inhibitor (K-i = 20 nM).
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