期刊
NEUROSCIENCE LETTERS
卷 397, 期 3, 页码 219-223出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.12.013
关键词
chemotherapy; paclitaxel; ALC; L-acetylcarnitine; ALCAR; pain
资金
- NINDS NIH HHS [R01 NS036834, R01-NS36834, R01 NS052255] Funding Source: Medline
This study examines the potential efficacy of acetyl-L-carnitine (ALC) to prevent and treat paclitaxel-induced pain. Rats received four intraperitoneal (i.p.) injections of 2 mg/kg paclitaxel on alternate days which, following a short delay induced marked mechanical hypersensitivity. Daily administration of ALC (50 mg/kg and 100 mg/kg; p.o.; concurrently with paclitaxel and for 14 days afterwards) prevented the development of paclitaxel-induced pain. This effect was long lasting, for at least 3 weeks after the last dose of ALC. In a separate experiment, daily administration of ALC (100 mg/kg; p.o.; for 10 days) to rats with established paclitaxel-induced pain produced an analgesic effect. This effect dissipated shortly after ALC treatment was withdrawn. We conclude that ALC may be useful in the prevention and treatment of chemotherapy-induced painful peripheral neuropathy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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