期刊
NEUROLOGY
卷 66, 期 8, 页码 1255-1257出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000208433.34723.65
关键词
-
资金
- NIMH NIH HHS [K23 MH066705, MH66705, K23 MH066705-03, K23 MH066705-01, K23 MH066705-04, K23 MH066705-02S1, K23 MH066705-02, K23 MH066705-05] Funding Source: Medline
- NINDS NIH HHS [R01 NS049465, NS049465, NS36519, P01 NS036519] Funding Source: Medline
Diffusion tension imaging (DTI) exploits the random translational movements of water molecules as a noninvasive mechanism for probing brain regions of interest (ROIs). 1 This strategy can be used to derive putative measurements of tissue injury in vivo. Diffusion abnormalities have been detected in patients with HIV, and DTI measurements correlate with cognitive status. 2 Markers of immune activation, monocyte chemoattractant protein 1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha) and of anemia (hematocrit) have been identified as potential determinants of HIV-dementia (HIV-D). (3) This investigation examined relationships between MCP-1, TNF-alpha, and hematocrit levels in plasma and measurements of the direction-dependent (anisotropy) and mean diffusivity quantified for regions that are vulnerable to injury in patients with HIV, including centrum semi-ovale, caudate, and putamen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据