期刊
ORGANIC LETTERS
卷 8, 期 9, 页码 1893-1896出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol060457z
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资金
- NCI NIH HHS [CA31845] Funding Source: Medline
The first member of a new class of five-membered B-ring analogs of bryostatin has been synthesized and tested for its ability to bind and translocate protein kinase C (PKC). This synthesis extends the utility of our previously introduced macrotransacetalization strategy to the formation of five-membered dioxolane B-ring analogs. This analog exhibits potent, single-digit nanomolar affinity to PKC and selectively translocates novel PKC isozymes.
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