期刊
CANCER LETTERS
卷 235, 期 2, 页码 260-265出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.04.032
关键词
metastasis suppressor gene; 4TI; breast cancer; murine ortholog
类别
资金
- NCI NIH HHS [CA 13148-31, CA89019, CA87728] Funding Source: Medline
The murine ortholog (Brms1) of human breast cancer metastasis suppressor 1 shares 95% identity to the human metastasis suppressor, BRMS1, in amino acid structure. We tested Brms1 for suppression of metastasis of mouse mammary carcinoma cell line 4T1 in syngenic BALB/c mice, using orthotopic (mammary fat pad) injection as well as intravenous injection. As observed for BRMS1, transfection with Brms1 did not inhibit 4T1 primary tumor formation, but significantly suppressed lung colonization. We also show that Brms1 protein interacts with histone deacetylases, indicating involvement of Brms1 in murine Sin3-HDAC complex, like its human counterpart. Thus, because of similarities with its human ortholog, the results suggest that Brms1 will be useful as a model for studying mechanism of action of BRMS1. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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