期刊
AQUACULTURE
卷 254, 期 1-4, 页码 160-170出版社
ELSEVIER
DOI: 10.1016/j.aquaculture.2005.10.016
关键词
disease-resistance; linkage mapping; AFLP markers; QTLs; Dermo; summer mortality; oyster; Crassostrea virginica
Identification and mapping of disease-resistance QTLs (quantitative trait loci) is important for our understanding of genetic mechanisms of disease-resistance and for our ability to genetically improve cultured stocks. Disease-resistance is the most important trait for farmers of the eastern oyster (Crassostrea virginica Gmelin), which is affected by two major diseases: MSX and Dermo. In this study, the genome of the eastern oyster was scanned with a large number of amplified fragment length polymorphism (AFLP) markers before and after Dermo-inflicted mortalities (53% and 67%) in two reference families. Significant post-mortality shifts in genotype frequency were detected at a large number of loci. Linkage analysis revealed that most markers showing frequency shifts are closely linked to each other on the genetic map, and all markers within a cluster had frequency shifts in the same direction according to their linkage phase. This finding suggests that post-mortality shifts in genotype frequency were not random, but linked to Dermo/summer mortality-resistance QTLs. Twelve putative Dermo/summer mortality-resistance QTLs were identified on female and male maps from two families, providing candidate genome regions for further analysis. (c) 2005 Elsevier B.V All rights reserved.
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