期刊
PLASMID
卷 55, 期 3, 页码 173-183出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.plasmid.2006.01.001
关键词
integrating conjugative element; ICE; Vibrio cholerae; gamma-proteobacteria; SXT; R391; antibiotic resistance
SXT is an integrating Conjugative element (ICE) that was initially isolated from a 1992 Vibrio cholerae 0 139 clinical isolate from India. This similar to 100-kb ICE encodes resistance to multiple antibiotics. SXT or closely related ICEs are now present in most clinical and some environmental V. cholerae isolates from Asia and Africa. SXT-related ICEs are not limited to V. cholerae. It is now clear that so-called IncJ elements such its R391 are closely related to SXT. More than 25 members of the SXT/R391 family of ICEs have now been identified in environmental and clinical isolates of diverse species of gamma-proteobacteria worldwide. In this review, we discuss the diversity, evolution and biology of this family of ICEs. (c) 2006 Elsevier Inc. All rights reserved.
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