期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 5, 页码 1893-1895出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.50.5.1893-1895.2006
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资金
- FIC NIH HHS [K01 TW000007, K01 TW 00007] Funding Source: Medline
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.
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