期刊
CURRENT HYPERTENSION REPORTS
卷 8, 期 2, 页码 158-165出版社
CURRENT SCIENCE INC
DOI: 10.1007/s11906-006-0013-z
关键词
-
The post-macula densa segments of the renal tubule that is, the distal convoluted tubule, connecting tubule, and collecting duct-play a central role in determining final urine sodium excretion. The major regulated sodium transporters and channels in these cell types include the thiazide-sensitive (Na-Cl) cotransporter (NCC), the epithelial sodium channel (ENaC), and Na-K-ATPase. Furthermore, although not involved in sodium reabsorption, the anion exchanger, pendrin, and the basolateral bumetanide-sensitive Na-K-2CI cotransporter (NKCCI or BSC2) have roles in blood-volume maintenance. Mutations in several of these major sodium transporters, channel subunits, and their regulatory proteins have been linked to human diseases such as Liddle's syndrome, Gitelman's syndrome, and Gordon's syndrome, emphasizing the need for appropriate regulation of sodium at these sites for maintenance of sodium balance and normotension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据