期刊
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
卷 20, 期 12, 页码 1958-1964出版社
WILEY
DOI: 10.1111/1756-185X.12589
关键词
aging; arthritis; chemokines; hydroxychloroquine; pain
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
AimOsteoarthritis (OA) is a major cause of morbidity and incapacity in the elderly. This study evaluates serum levels of the chemokines CCL2, CXCL8, CXCL9, and CXCL10 in 16 patients with primary OA of the knees, and investigates how treatment with hydroxychloroquine (HCQ) for 4months affects these chemokine levels. MethodThirteen elderly patients received a placebo. Healthy control groups consisted of 10 elderly individuals (age >60years) with no clinical or radiological evidence of OA (CT-O), and 10 young adult individuals, (CT-Y group, age <40years). ResultsThe CT-Y group presented lower levels of all chemokines studied, in comparison to the other groups. HCQ treatment did not alter the serum levels of CCL2 (P=0.80), CXCL8 (P=0.76), CXCL9 (P=0.95) and CXCL10 (P=0.74) in OA patients. ConclusionHydroxychloroquine treatment did not alter the serum levels of CCL2, CXCL8, CXCL9 or CXCL10 in patients with OA of the knees, although increased serum levels correlated with aging for all subjects, including controls.
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