期刊
PROTEOMICS
卷 6, 期 10, 页码 3109-3113出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pmic.200500717
关键词
affinity chromatography; biomarker; 2-DE; non-human primate; serum
资金
- NIDA NIH HHS [R01 DA 013770] Funding Source: Medline
Non-human primates are an important biomedical research model organism and offer great promise for serum biomarker proteomic studies. However, potential obstacles to these studies include affinity serum depletion methods based on human antigens, depletion methods altering quantitation, and incomplete non-human primate genome sequences for protein identification. In the present study, high-abundance protein removal from monkey serum using a human multiple affinity removal system (MARS) was shown to be specific and did not alter quantitation. Depleted serum also demonstrated greater sensitivity for previously masked, lower-abundance proteins.
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