期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 9, 页码 2496-2499出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.079
关键词
erythromycin A; erythromycin derivative; immunomodulatory activity; NMR; molecular dynamics; three-dimensional solution structure; alignment; QSAR
EM703, which is an erythromycin derivative synthesized by Our group, has a potent promoting activity of monocyte-to-macrophage differentiation in vitro. Its activity is approximately 300 times higher than that of erythromycin A (EM-A). In this study, we determined three-dimensional (3D) solution structures of EM703 and EM-A, and compared them using a superposition method, in order to investigate the 3D structure-activity relationship. We found a distinct difference between the 3D structures of these molecules, which might be an important factor in their divergent activities. (C) 2006 Elsevier Ltd. All rights reserved.
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