期刊
JOURNAL OF BIOCHEMISTRY
卷 139, 期 5, 页码 837-846出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvj095
关键词
glycoprotein; hemagglutinin; human influenza B virus; lineage; membrane fusion; RNA aptamer
Aptamers are known for their higher discriminating ability between closely related molecules and their requirement for only a small region for binding, as compared to an antibody. In the present studies, we have isolated a specific RNA aptamer against the influenza virus B/Johannesburg/05/1999 by an in vitro selection procedure. The aptamer bound efficiently to the HA of influenza B and required 5 MM MgCl2 ion for its recognition. The aptamer not only distinguished RA derived from the influenza A virus, but also inhibited HA-mediated membrane fusion.
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