期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 9, 页码 2467-2469出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.100
关键词
thiopyrimidine; metabotropic glutamate receptor; mGluR5
Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity. (C) 2006 Elsevier Ltd. All rights reserved.
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