期刊
ANNALS OF PLASTIC SURGERY
卷 62, 期 3, 页码 317-321出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SAP.0b013e31817f01b6
关键词
wound healing; adipose tissue-derived stromal cells; db/db mice
类别
Adipose tissue-derived stromal cells (ATSCs) have recently gained widespread attention as a potential alternate source to bone marrow-derived mesenchymal stem cells with a proliferative capacity and a similar ability to undergo multilineage differentiation. In this study, we evaluated the effectiveness of freshly isolated autologous ATSCs-containing atelocollagen matrix with silicon membrane (ACMS) oil wound healing of diabetic (db/db) mice. Cultured ATSCs from (db/db) mice secreted significant amounts Of growth factors and cytokines, which are suitable for wound repair. Two full thickness round skin detects were made on the backs of healing-impaired db/db mice. Freshly isolated autologous ATSCs-containing ACMS or ACMS alone were applied to the wounds. Twelve mice were treated and then killed at I or 2 weeks (n = 6 each). Histologic sections of the wounds were prepared at each little period after treatment. Histologic examination demonstrated significantly advanced granulation tissue formation, capillary formation, and epithelialization in diabetic healing-impaired wounds treated with autologous ATSCs-containing ACMS, compared with mice treated with ACMS alone. These results Suggested that transplantation of autologous ATSCs-containing ACMS significantly accelerated Wound healing in diabetic healing-impaired db/db mice.
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