期刊
MAGNETIC RESONANCE IMAGING
卷 24, 期 4, 页码 527-539出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2006.01.003
关键词
C-13 NMR spectroscopy; metabolic modeling; TCA cycle; glutamatergic neurotransmission; compartmentation
资金
- NCRR NIH HHS [M01-RR00400, P41-RR08079] Funding Source: Medline
- NINDS NIH HHS [R01-NS38672] Funding Source: Medline
In vivo C-13 NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the C-13 labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues. (c) 2006 Elsevier Inc. All rights reserved.
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