期刊
INFECTION AND IMMUNITY
卷 74, 期 5, 页码 3046-3051出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.5.3046-3051.2006
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资金
- NIDDK NIH HHS [R01 DK53623, R01 DK053623] Funding Source: Medline
Helicobacter pylori babA encodes an outer membrane protein that binds to fucosylated Lewis b blood group antigen. We analyzed a panel of 35 H. pylori strains and identified three possible chromosomal loci for babA. There was a significant association between the presence of babA and the presence or cagA (P = 0.0001). Phylogenetic analysis of babA alleles revealed two divergent families of signal sequences. Among 17 strains in which an intact in-frame babA allele was identified, 10 expressed a detectable BabA protein. Expression of a BabA protein and the Lewis b-binding phenotype were not dependent on the chromosomal locus of babA. These data indicate that there is marked heterogeneity among H. pylori strains in babA genetic content and BabA expression.
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