期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 17, 期 4, 页码 150-158出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2006.03.007
关键词
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Recently, a new class of regulatory molecules has emerged; these molecules, termed SOCS proteins, function as suppressors of cytokine signaling. SOCS proteins negatively regulate the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling cascade. Interestingly, it appears that other proteins, such as caveolin-1, can also function as suppressors of cytokine signaling by inhibiting the kinase activity of JAK family members. This might result from the ability of caveolin-1 to function as a broadspectrum kinase inhibitor through the caveolin-scaffolding domain.
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