期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 25, 期 3-4, 页码 135-154出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830180600743057
关键词
adjuvant; CpG; innate; oligodeoxynucleotide; Th1
类别
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Thl and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5- to 500-fold. The CpG motifs present in bacterial DNA plasmids may contribute to the immunogenicity of DNA vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans and can improve vaccine-induced immune responses.
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