期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 32, 期 5, 页码 769-775出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2006.01.017
关键词
Wistar rat calvaria; mechanism; NO synthase; protein kinase; inositol phosphate pathway; Ca2+ release; stretch activated ion channel; calmodulin; enhanced bone repair
This study compares the mechanisms of ultrasound (US) on osteoblast proliferation with those of pulsed electromagnetic field (PEMF), by different signal transduction pathway inhibitors. The cells were stimulated for 15 min under US or for 2 h under PEMF exposure. Twenty-four h after the beginning of stimulation, the cells were harvested and used for mitochondrial activity test (MTT) analysis. The results showed that there are different transduction pathways for US and PEMF stimulation that lead to an upgrade of osteoblast proliferation, although their pathways all lead to an increase in cytocolic Ca2+ and activation of calmodulin. These findings offer a biochemical mechanism to support the process of ultrasound and PEMF-induced enhanced healing of bone fractures. (E-mail: whchang@cycu.edu.tw) (c) 2006 World Federation for Ultrasound in Medicine & Biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据