期刊
TRENDS IN NEUROSCIENCES
卷 29, 期 5, 页码 286-293出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2006.03.006
关键词
-
资金
- NIEHS NIH HHS [ES 13941] Funding Source: Medline
- NINDS NIH HHS [P01 NS 40256] Funding Source: Medline
Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been linked recently with autosomal-dominant parkinsonism that is clinically indistinguishable from typical, idiopathic, late-onset PD. Thus, the protein LRRK2 has emerged as a promising therapeutic target for treatment of PD. LRRK2 is extraordinarily large and complex, with multiple enzymatic and protein-interaction domains, each of which is targeted by pathogenic mutations in familial PD. This review places the PD-associated mutations of LRRK2 in a structural and functional framework, with the ultimate aim of deciphering the molecular basis of LRRK2-associated pathogenesis. This, in turn, should advance our understanding and treatment of familial and idiopathic PD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据