期刊
PEDIATRICS
卷 117, 期 5, 页码 1626-1631出版社
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2005-1767
关键词
periventricular leukomalacia; MRI; brain injury; patent ductus arteriosus; indomethacin
类别
资金
- NCRR NIH HHS [5 M01 RR-01271] Funding Source: Medline
- NHLBI NIH HHS [HL466911, HL56061] Funding Source: Medline
- NINDS NIH HHS [NS40117, NS35902, NS046432] Funding Source: Medline
OBJECTIVES. Newborns delivered before 28 weeks' gestation commonly have white matter lesions on MRI that are associated with adverse neurodevelopmental outcomes. Our objective was to determine the risk factors for MRI-detectable white matter injury in infants delivered before 28 weeks' gestation who were treated with prophylactic indomethacin. METHODS. This was a prospective cohort study conducted at the intensive care nursery at University of California San Francisco Children's Hospital. Patients included 57 premature newborns between 24 and 27 ( +6 days) weeks' gestation at birth ( October 1998 to October 2004). We identified perinatal and neonatal risk factors associated with moderate-severe white matter injuries ( T1 signal abnormalities > 2 mm or > 3 areas of T1 abnormality) and moderate-severe brain abnormality ( moderate-severe white matter injuries, any degree of ventriculomegaly, or severe intraventricular hemorrhage) on MRI. Infants were studied with MRI at 31.1 weeks' postmenstrual age ( median). RESULTS. Moderate-severe white matter injuries were detected in 12 ( 21%) of 53 preterm newborns, and 20 ( 35%) of 57 had moderate-severe brain abnormality. Prolonged indomethacin exposure was the only risk factor independently associated with a lower risk of white matter injury or brain abnormality, even when adjusting for the presence of a hemodynamically significant PDA, gestational age at birth, prenatal betamethasone, systemic infection, and days of mechanical ventilation. CONCLUSIONS. In this observational study, a longer duration of indomethacin exposure was associated with less white matter injury in infants delivered before 28 weeks' gestation. A randomized trial of prolonged indomethacin treatment is needed to determine whether indomethacin can decrease white matter injury and neurodevelopmental abnormalities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据