期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 37, 期 3, 页码 279-286出版社
ELSEVIER
DOI: 10.1016/j.supflu.2005.09.005
关键词
drug nanoparticles; supercritical fluid; RESOLV; stabilization; ibuprofen
Rapid expansion of a supercritical solution into a liquid solvent (RESOLV) was applied to the nanosizing of ibuprofen particles in aqueous suspension. When the rapid expansion was into neat water, the initially formed nanoscale ibuprofen particles agglomerated into large aggregates. Various water-soluble polymers of different molecular weights were added to the aqueous receiving medium in RESOLV as stabilization agent for the produced nanoparticle suspension, and their effects on the properties of the harvested ibuprofen nanoparticles were evaluated. A conclusion is that the selection of stabilization agent in RESOLV may also be used to alter the sizes and morphology of the nanosized drug particles. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据