期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 8, 期 3, 页码 295-301出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejheart.2005.11.008
关键词
aldosterone; heart failure; left ventricular systolic dysfunction; eplerenone; EPHESUS
Aims: Because of the prognostic importance of LV dysfunction following an AMI and the increasing use of electrical and/or mechanical interventions in patients with LV systolic dysfunction, this retrospective analysis of EPHESUS patients with LVEF <= 30% at baseline was conducted to determine the value of eplerenone in this setting. Methods and results: In EPHESUS, 6632 patients with LVEF <= 40% and clinical heart failure (HF) post-AMI who were receiving standard therapy were randomized to eplerenone 25 mg/day titrated to 50 mg/day or placebo for a mean follow-up of 16 months. Treatment with eplerenone in the subgroup of patients with LVEF <= 30% (N = 2106) resulted in relative risk reductions of 21% versus placebo in both all-cause mortality (P=0.012) and cardiovascular (CV) mortality/CV hospitalization (P=0.001), and 23% for CV mortality (P=0.008). The relative risk of sudden cardiac death (SCD) was reduced 33% (P=0.01) and HF mortality/HF hospitalization was reduced 25% (P=0.005) with eplerenone compared with placebo. Within 30 days of randomization, eplerenone resulted in relative risk reductions of 43% for all-cause mortality (P=0.002), 29% for CV mortality/CV hospitalization (P=0.006), and 58% for SCD (P=0.008). Conclusions: Treatment with eplerenone plus standard therapy in patients with post-AMI HF and LVEF <= 30% provided significant incremental benefits in reducing both early and late mortality and morbidity. (c) 2005 European Society of Cardiology Published by Elsevier B.V. All rights reserved.
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