期刊
EUROPEAN JOURNAL OF CANCER
卷 42, 期 8, 页码 1040-1043出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.01.022
关键词
FISH; steroidogenic factor 1 (SF-1); adrenal cortex; childhood tumours
类别
资金
- NCI NIH HHS [CA21765, CA71907] Funding Source: Medline
The steroidogenic factor I (SF-1) gene encodes a transcription factor playing a pivotal role in the regulation of adrenogenital development. We have recently shown that SF-I is amplified in childhood adrenocortical tumours (ACT). This study was aimed to assess if an increase in SF-1 gene copy number was associated with increased protein levels and to study the correlation between SF-1 expression and ACT clinical parameters. An increased SF-1 copy number was detected in eight of the 10 ACT cases studied. Conversely, the SF1 protein was found to be overexpressed in all cases, compared to normal age-matched adrenal glands. No significant correlation was found between SF-1 protein levels and its gene copy number. Furthermore, no significant correlation existed with histological grade or with the clinical manifestation or evolution of disease. This data show that SF-1 overexpression is widespread in childhood ACT and is likely to play a role in its pathogenesis. (c) 2006 Elsevier Ltd. All rights reserved.
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