期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 5, 页码 1701-1709出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.50.5.1701-1709.2006
关键词
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We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
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