期刊
NATURE NEUROSCIENCE
卷 9, 期 5, 页码 599-601出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1685
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资金
- Medical Research Council [G0000114] Funding Source: Medline
- NIGMS NIH HHS [R01 GM038679-18, R01 GM059642, R01 GM038679, R01 GM059642-11] Funding Source: Medline
- MRC [G0000114] Funding Source: UKRI
- Medical Research Council [G0000114] Funding Source: researchfish
Acetylcholine, a major excitatory neurotransmitter in Caenorhabditis elegans, is transported into synaptic vesicles by the vesicular acetylcholine transporter encoded by unc-17. The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain. These results suggest an association of vesicular soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) components with vesicular neurotransmitter transporters.
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