期刊
JOURNAL OF VIROLOGY
卷 80, 期 10, 页码 5082-5085出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.10.5082-5085.2006
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资金
- Intramural NIH HHS Funding Source: Medline
Adeno-associated viruses (AAVs) depend on a helper virus for efficient replication. To identify novel AAV isolates, we screened a diverse set of virus isolates for the presence of AAV DNA. AAVs found in 10 simian adenovirus isolates showed greater than 96% homology to AAV1 and AAV6 but had distinct biological properties. Two representatives of this group, AAV(VR-195) and AAV(VR-355), were studied in more detail. While the novel AAVs had high sequence homologies and required sialic acid for cell binding and transduction, differences were observed in lectin competition, resulting in distinct tropisms in human cancer cell lines.
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