期刊
CRITICAL CARE MEDICINE
卷 34, 期 5, 页码 S124-S131出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.CCM.0000214292.62276.8E
关键词
neutrophils; endothelium; lipids; adhesion; innate immunity
资金
- NHLBI NIH HHS [HL 59355] Funding Source: Medline
- NIGMS NIH HHS [2P50 GM 49222] Funding Source: Medline
The objective of this review is to present the two-event model of transfusion-related acute lung injury (TRALI), a life-threatening complication of transfusions that has been the most common cause of transfusion-related death over the past 2 yrs in the United States. The two-event model of TRALI, which is identical to the pathogenesis of the acute respiratory distress syndrome (ARDS), is reviewed and contrasted to antibody-mediated TRALI. Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed.
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