期刊
CANCER CELL
卷 9, 期 5, 页码 405-416出版社
CELL PRESS
DOI: 10.1016/j.ccr.2006.04.004
关键词
-
资金
- NCI NIH HHS [K08 CA096755, K08 CA096755-05, K08 CA96755] Funding Source: Medline
Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By combining retroviral-mediated RNA interference with reexpression studies, we show that ongoing EWS/FLI expression is required for the tumorigenic phenotype of Ewing's sarcoma. We used this system to define the full complement of EWS/FLI-regulated genes in Ewing's sarcoma. Functional analysis revealed that NKX2.2 is an EWS/FLI-regulated gene that is necessary for oncogenic transformation in this tumor. Thus, we developed a highly validated transcriptional profile for the EWS/FL1 fusion protein and identified a critical target gene in Ewing's sarcoma development.
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