期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 133, 期 4, 页码 436-438出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2006.06051.x
关键词
phospholipids; red blood cell membrane; haemoglobinopathies
类别
资金
- NHLBI NIH HHS [HL070583] Funding Source: Medline
The asymmetric distribution of amino-containing phospholipids in plasma membranes is essential for the function and survival of mammalian cells. Phosphatidylserine (PS) is restricted to the inner leaflet of plasma membranes by an ATP-dependent transport process. Exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology. We report the identification of two different isoforms of the aminophospholipid translocase, Atp8a1, or flippase, in the murine red blood cell membrane.
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