期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 54, 期 5, 页码 682-686出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.682
关键词
biscoumarins; HIV-1 integrase; inhibitor
Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.
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