期刊
NEUROBIOLOGY OF AGING
卷 27, 期 5, 页码 681-690出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.03.015
关键词
dementia; Alzheimer's disease; cognition; PET; CERAD
The present study examined the cortical functional representation of neuropsychological domains in Alzheimer's disease (AD) using positron emission tomography (PET) and the neuropsychological assessment battery of the Consortium to Establish it Registry of Alzheimer's Disease (CERAD). Thirty patients with clinical probable AD and 10 elderly healthy controls underwent (18)FDG brain PET imaging during a resting state. Correlations between metabolic values and cognitive measures were determined using a re-ion of interest analysis with NEUROSTAT (University of Michigan, USA) and it voxel-based analysis with SPM96 (Wellcome Department, London, UK). Specific correlations were seen between measures of episodic memory, verbal fluency and naming and left hemispheric temporal and prefrontal metabolism. Drawing was correlated with metabolism in left prefrontal and left interior parietal regions. The presented data Support the use of metabolic-cognitive correlations to demonstrate the neuronal Substrates of cognitive impairment in AD. Subtests of the CERAD battery give a good representation of left, but not of right hemisphere function in AD. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据