期刊
PEPTIDES
卷 27, 期 5, 页码 1121-1129出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2005.06.036
关键词
RF-amide peptides; LPXRF-amide peptides; gonadotropin-inhibitory hormone (GnIH); frog growth hormone releasing peptide (fGRP); hypothalamus; pituitary; hypophysiotropic activity
Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function in vertebrates is essential for the progress of neuroendocrinology. Recently, we identified a novel hypothalamic neuropeptide with a C-terminal LPLRF-amide sequence in the quail brain. This avian neuropeptide was shown to be located in the hypothalamohypophysial system and to decrease gonadotropin release from cultured anterior pituitary. We, therefore, designated this novel neuropeptide as gonadotropin-inhibitory hormone (GnIH). We further identified novel hypothalamic neuropeptides closely related to GnIH in the brains of other vertebrates, such as mammals, amphibians, and fish. The identified. neuropeptides possessed a LPXRF-amide (X = L or Q) motif at their C-termini. These LPXRF-amide peptides also were localized in the hypothalamus and other brainstem areas and. regulated pituitary hormone release. Subsequently, cDNAs that encode LPXRF-amide peptides were characterized in vertebrate brains. In this review, we summarize the identification, localization, and hypophysiotropic activity of these newly identified hypothalamic LPXRF-amide peptides in vertebrates. (c) 2006 Elsevier Inc. All rights reserved.
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