期刊
GASTROENTEROLOGY
卷 130, 期 6, 页码 1721-1728出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2006.01.045
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Background & Aims: Although inflammatory and immune cells are present in the gut in the absence of pathology, their presence does not result in sensitization of sensory nerves, implying the existence of a local antinociceptive influence. We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort. Methods: Visceromotor responses to colorectal distention were measured in mice with severe combined immune deficiency (SCID) and their wild-type controls. Results: SCID mice exhibited significantly lower pain thresholds. Transfer of CD4(+) T, but not B lymphocytes, normalized visceral pain in these mice. The restoration of normal visceral nociception following T-cell reconstitution in SCID mice was blocked by naloxone methiodide. Using an enzyme immunoassay and immunohistochemistry for P-endorphin, we showed that in vitro stimulation of T lymphocytes induced the synthesis and release of P-endorphin and that transfer of T cells into SCID mice increased the expression of P-endorphin in the enteric nervous system. Conclusions: These findings indicate that the immune system is a critical determinant of visceral nociception and that T lymphocytes provide an important opioid-mediated antinociceptive influence in the gut.
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