期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 25, 期 3-4, 页码 235-258出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830180600743081
关键词
autoimmunity; avidity; T-cell; tolerance; tuning
类别
资金
- NCI NIH HHS [R01 CA109536] Funding Source: Medline
Thymic T-cell selection mechanisms generate a cross-reactive, self-MHC restricted peripheral T-cell pool. Affinity and avidity are of profound influence on this selection and the generation of immunity. Autoreactive T cells can escape thymic deletion by lowering their avidity and retain this tuned state in the periphery. Upon activation, tuned T cells can cause autoimmunity, while immunotherapeutic strategies may be hampered by existing T-cell tolerance. The regulation of T-cell avidity and tuning therefore determines the balance between tolerance and autoimmunity and should be taken into account in the design of therapeutic strategies aimed at T-cell reactivity.
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