Expression of HER1/EGFR protein in human soft tissue sarcomas

Aim: To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples. Method: HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients. Results: HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues. Conclusion: HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown. (C) 2006 Elsevier Ltd. All rights reserved.