期刊
CELLULAR SIGNALLING
卷 18, 期 5, 页码 679-687出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2005.06.015
关键词
cell growth; squamous cell carcinoma; TNF; apoptosis; Wnt
类别
资金
- NCI NIH HHS [CA 100849] Funding Source: Medline
- NIDCR NIH HHS [DE13848, DE015964] Funding Source: Medline
The Wnt/beta-catenin signaling pathway plays a critical role in cell proliferation and oncogenesis. It has been found to be chronically activated in a variety of human cancers, including head and neck squamous cell carcinoma (HNSCC). Previously, we have found that the activation of the Wnt/beta-catenin signaling pathway inhibits mitochondria-mediated apoptosis. In this study, we extended our studies to determine whether the Wnt/beta-catenin signaling pathway inhibited death receptor-mediated apoptosis in HNSCC cells. We found that Wnt/pcatenin inhibited not only tumor necrosis factor (TNF)/c-Myc-mediated apoptosis, but also cell detachment-mediated apoptosis (anoikis) which is dependent on the death receptor signaling pathway. Interestingly, we also observed that the Wnt/beta-catenin signaling pathway induced HNSCC cell scattering and promoted cell invasion in the Matrigel, both of which are hallmarks for the invasive growth of HNSCC. Consistently, the over-expression of beta-catenin promoted HNSCC tumor growth in nude inice. Taken together, our results suggest that the Wnt/ beta-catenin signaling pathway plays dual functions in HNSCC development: promoting both cell survival and invasive growth of HNSCC cells. (c) 2005 Published by Elsevier Inc.
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