期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 85, 期 3, 页码 283-288出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2005.12.001
关键词
dopamine; dopamine transporter; learning; instrumental conditioning; operant; inhibitory control
资金
- NIMH NIH HHS [MH66216, MH56446] Funding Source: Medline
In two experiments we investigated the effects of elevated dopaminergic tone on instrumental learning and performance using dopamine transporter knockdown (DAT KD) mice. In Experiment 1, we showed that both DAT KD mice and wild-type controls were similarly sensitive to outcome devaluation induced by sensory specific satiety, indicating normal action-outcome learning in both groups. In Experiment 2, we used a Pavlovian-to-instrumental transfer procedure to assess the potentiation of instrumental responding by Pavlovian conditional stimuli (CS). Although during the Pavlovian training phase the DAT KID mice entered the food magazine more frequently in the absence of the CS, when tested later both groups showed outcome-selective PIT. These results suggest that the elevated dopaminergic tone reduced the selectivity of stimulus control over conditioned behavior, but did not affect instrumental learning. (c) 2005 Elsevier Inc. All rights reserved.
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