期刊
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
卷 16, 期 3, 页码 1374-1378出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1525-1438.2006.00561.x
关键词
biomarkers; endometrial cancer; mass spectrometry; proteomics
To find new potential biomarkers for detection of endometrial cancer (EC), 70 serum samples including 40 from EC patients and 30 from normal healthy females were detected by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) using WCX2 (weak cation exchange) protein chip. Mass spectra were then assessed with three powerful data-mining tools: a tree classifier, Biomarker Wizard software, and Biomarker Patterns System. The diagnostic pattern combined with 13 potential biomarkers could differentiate EC patients from healthy persons, with a specificity of 100%, sensitivity of 92.5%, and total coincidence of 95.7%. The combination of surface-enhanced laser desorption-ionization with bioinformatics tools could help find new biomarkers and establish with high sensitivity and specificity for the detection of EC.
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