期刊
SYNLETT
卷 -, 期 7, 页码 1059-1062出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-939701
关键词
organocatalysis; aldol reaction; asymmetric synthesis; binaphtyl; proline
A series of L-prolineamides derived from various aromatic diamines including 1,1'-binaphthyl-2,2'-diamine, were prepared in good yields. They were evaluated as catalysts for the direct asymmetric aldol reaction. The presence of the binaphthyl and proline moieties in one molecule has beneficial effects oil the stereochemical outcome of the reaction of acetone with a model aldehyde. Furthermore, it was shown that dioxane as the solvent significantly improved both yield and enantioselectivity, reaching 89% and 86%, respectively.
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