期刊
SCIENCE
卷 312, 期 5774, 页码 738-741出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1123940
关键词
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资金
- PHS HHS [G64713] Funding Source: Medline
B cells recognize foreign antigens by virtue of cell surface immunoglobulin receptors and are most effectively activated by membrane-bound ligands. Here, we show that in the early stages of this process, B cells exhibit a two-phase response in which they first spread over the antigen-bearing membrane and then contract, thereby collecting bound antigen into a central aggregate. The extent of this response, which is both signaling- and actin-dependent, determines the quantity of antigen accumulated and hence the degree of B cell activation. Brownian dynamic simulations reproduce essential features of the antigen collection process and suggest a possible basis for affinity discrimination. We propose that dynamic spreading is an important step of the immune response.
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