期刊
ORGANIC LETTERS
卷 8, 期 10, 页码 2023-2026出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol060414i
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-
资金
- NCI NIH HHS [U01CA085133, U01 CA085133-01, U01 CA085133] Funding Source: Medline
Lysophospholipase D (lysoPLD), also known as autotaxin (ATX), is an important source of the potent mitogen lysophosphatidic acid (LPA). Two fluorogenic substrate analogues for lysoPLD were synthesized in nine steps from (S)-PMB-glycerol. The substrates (FS-2 and FS-3) show significant increases in fluorescence when treated with recombinant ATX and have potential applications in screening for this emerging drug target.
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