期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 10, 页码 2672-2676出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.02.025
关键词
EGFR tyrosine kinase; kinase inhibition; anilinoquinazoline
The structure-activity relationship of a novel subseries of 4-anilinoquinazoline EGFR inhibitors substituted at the C-6 position with carbon-linked side chains has been investigated. This exploration has led to the discovery of novel aminomethyl carboxamides with good biological, pharmacokinetic and physical properties. (C) 2006 Elsevier Ltd. All rights reserved.
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