期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 10, 页码 3447-3454出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.01.002
关键词
taxol; paclitaxel; tubulin; cytotoxicity; molecular modeling; synthesis; olefin metathesis
资金
- NCI NIH HHS [R01 CA069571, R01 CA069571-10, R01 CA069571-11, R01 CA069571-12] Funding Source: Medline
A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself. (c) 2006 Elsevier Ltd. All rights reserved.
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