期刊
BEHAVIOURAL BRAIN RESEARCH
卷 169, 期 2, 页码 206-211出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.01.014
关键词
capsular-infarct; white-matter; endothelin-1; animal model
资金
- NICHD NIH HHS [HD02528, HD07523] Funding Source: Medline
- NINDS NIH HHS [NS 30853] Funding Source: Medline
In this study stereotaxic injections of the vasoconstrictive peptide endothelin-1 (ET-1) were used to create infarcts in the white matter of the internal capsule underlying sensorimotor cortex in rats. Resulting deficits were assessed using established sensorimotor tests conducted on each rat before and after the ET1-induced infarct. After a 14-day survival period, histological examination revealed tissue necrosis and demyelination in the infarcted white matter of ET1-injected rats, but not saline-injected control rats. Infarcts resulted in measurable sensorimotor deficits in rats that received ET-1 injections. The same sensorimotor tests showed no deficits in surgical-control rats. The present model of white matter infarct should be valuable in examining the underlying mechanisms of subcortical ischemic stroke and to evaluate potential therapeutic interventions. (C) 2006 Elsevier B.V. All rights reserved.
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