期刊
TETRAHEDRON
卷 62, 期 20, 页码 4907-4916出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.03.017
关键词
asymmetric synthesis; reduction; gamma and delta-lactams; cobalt chloride; sodium borohydride
Sodium borohydride in combination with a catalytic amount of CoCl, has been found to be an excellent catalytic system in reductive cyclizations of suitably substituted azido and cyano groups of alpha,beta-unsaturated esters to afford gamma and delta-lactams in high yields. The process has been demonstrated for the enantioselective synthesis of (R)-baclofen, (R)-rolipram, and (R)-4-fluorophenylpiperidinone, a key intermediate for (-)-paroxetine. (c) 2006 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据