期刊
FEBS LETTERS
卷 580, 期 12, 页码 2853-2859出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.03.086
关键词
transduction; sensory; adaptation; olfaction; cAMP; channelopathy
Cyclic nucleotide-gated (CNG) channels, directly activated by the binding of cyclic nucleotides, were first discovered in retinal rods, cones and olfactory sensory neurons. In the visual and olfactory systems, CNG channels mediate sensory transduction by conducting cationic currents carried primarily by sodium and calcium ions. In olfactory transduction, calcium in combination with calmodulin exerts a negative feedback on CNG channels that is the main molecular mechanism responsible for fast adaptation in olfactory sensory neurons. Six mammalian CNG channel genes are known and some human visual disorders are caused by mutations in retinal rod or cone CNG genes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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