期刊
NEUROSCIENCE LETTERS
卷 399, 期 3, 页码 245-248出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.02.001
关键词
chromosome 22q11.2; VCFS; cerebellum; visuospatial; psychopathology
Children with chromosome 22q11.2 deletion syndrome commonly are found to have morphological brain changes, cognitive impairments, and elevated rates of psychopathology. One of the most commonly and consistently reported brain changes is reduced cerebellar volume. Here, we demonstrate that, in addition to the global cerebellum reductions previously reported, volumetric reductions of the anterior lobule and the vermal region of the neo-cerebellum in the mid-sagittal plane best differentiate children with the deletion from typically developing children. These results suggest that the morphological changes of specific portions of the cerebellum may be an important underlying substrate of cognitive impairments and increased incidence of psychopathology in this group. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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