期刊
CURRENT BIOLOGY
卷 16, 期 10, 页码 982-989出版社
CELL PRESS
DOI: 10.1016/j.cub.2006.03.062
关键词
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资金
- Medical Research Council [MC_U105178780] Funding Source: researchfish
- MRC [MC_U105178780] Funding Source: UKRI
- Medical Research Council [MC_U105178780] Funding Source: Medline
In addition to being energy generators, mitochondria control many cellular processes including apoptosis [1]. They are dynamic organelles, and the machinery of membrane fusion and fission is emerging as a key regulator of mitochondrial biology [2]. We have recently identified a novel and conserved mitochondrial rhomboid intramembrane protease that controls membrane fusion in Saccharomyces cerevisiae by processing the dynamin-like GTPase, Mgm1, thereby releasing it from the membrane [3]. The genetics of mitochondrial membrane dynamics has until now focused primarily on yeast [4]. Here we show that in Drosophila, the mitochondrial rhomboid (Rhomboid-7) is required for mitochondrial fusion during fly spermatogenesis and muscle maturation, both tissues with unusual mitochondrial dynamics. We also find that mutations in Drosophila optic atrophy 1-like (Opal-like), the ortholog of yeast mgm1, display similar phenotypes, suggesting a shared role for Rhomboid-7 and Opa1-like, as with their yeast orthologs. Loss of human OPA1 leads to dominant optic atrophy, a mitochondrial disease leading to childhood onset blindness. rhomboid-7 mutant flies have severe neurological defects, evidenced by compromised signaling across the first visual synapse, as well as light-induced neurodegeneration of photoreceptors that resembles the human disease. rhomboid-7 mutant flies also have a greatly reduced lifespan.
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